The TEIDe project aims to identify individuals at high risk of dementia and enhance understanding of the interplay between exercise and cognitive aging. We will establish an integrated framework, combining predictive, precision, mechanistic, and clinical application approaches for the effective prevention of dementia.

 The four main research questions focus on (i) the discriminative power of dementia risk scores; (ii) optimal types and doses of exercise that confer cognitive benefits based on individual patient characteristics; (iii) the underlying mechanisms of the effect of exercise on cognition; and (iv) the feasibility of implementing a holistic approach in primary healthcare settings. For this, we leverage data from existing cohort studies with over 3 million people and from 7 completed and rigorously conducted exercise-based randomized control trials (RCTs) in middle-aged and older- aged adults with a range of cognitive function. With nine partners from eight countries (i.e., Spain, Norway, Germany, Italy, Slovakia, Romania, USA and Canada), the consortium combines academia, healthcare, enterprise, and operational stakeholders. This Project will generate at least four products which can be implemented in healthcare systems in the relatively short term such as (i) dementia risk scores, (ii) exercise prescription algorithms, (iii) user-friendly exercise manuals, and (iv) modifiable risk factors for non-pharmaceutical treatment.

The deliverables will benefit patients and clinicians, contributing to the prevention of cognitive decline and early-stage Alzheimer´s disease, promoting personalized medicine in dementia care. The TEIDe project stands as a collaborative effort to advance world-class research and strengthen research links, paving the way for improved prediction of treatment benefits and personalized interventions.