Overview: The OptimaMind project is a groundbreaking research initiative, focusing on Time-Restricted Eating (TRE) as a method to enhance brain health and tackle aging challenges. Historically, intermittent fasting was a natural part of life, with sporadic access to food. This project revisits these historical eating patterns to explore their benefits in the modern context, particularly for cognitive health.

Methodology: TRE has been observed to trigger adaptive changes that bolster cellular defenses and improve both physical and cognitive performance. This includes reducing systemic inflammation and increasing cellular antioxidant potential. A key outcome of TRE is the production of beta-hydroxybutyrate (BHB), a ketone body that enhances brain energy metabolism and cognitive functions. OptimaMind aims to conduct an extensive analysis of how TRE affects neuroprotective and neurogenerative biomarkers, especially in aging populations. Employing techniques like liquid chromatography-tandem mass spectrometry, ELISA, and immunofluorescent assays, the project will analyze existing biobank samples and diverse fasting protocol data from across Europe. This research will adhere to ethical standards and Responsible Research and Innovation guidelines.

Expected outcomes: The project´s expected outcomes are significant insights into TRE as a non-pharmacological approach to improving cognitive longevity and preventing dementia. These findings are anticipated to have a substantial impact on public health recommendations, clinical practices, and the wellness industry, ultimately enhancing cognitive health and quality of life in aging populations. This research holds potential benefits for both the scientific community and society, offering practical, evidence-based strategies for maintaining brain health.

Timeline: OptimaMind is poised to deliver findings within 3-5 years, contributing to the broader conversation on aging and brain health.