This study investigates an innovative approach to combat multiresistant bacterial infections through targeted MXene-assisted photothermal therapy. With the increasing threat of antibiotic resistance, developing alternative and effective antibacterial strategies is imperative. The unique combination of MXene nanoparticles and precision-targeting using specific antibodies, offers a promising solution.

The MXene-assisted photothermal therapy leverages the ability of MXene to efficiently convert near-infrared (NIR) light into heat. This photothermal conversion induces localized hyperthermia, targeting bacterial cells while minimizing tissue damage. The specificity is further enhanced by incorporating antibodies tailored to recognize and bind to multiresistant bacterial strains, particularly Methicillin-resistant Staphylococcus aureus (MRSA).

The study focuses on optimizing the structural composition of the MXene-assisted complex to maximize photothermal efficiency. The complex adapts to specific application requirements through meticulous tunability, ensuring versatility in addressing diverse multiresistant bacterial infections.

 Additionally, in vivo trials will be performed using a mice purulent wound model to simulate real-life infection scenarios. The complex will be applied to evaluate its effectiveness in eradicating multiresistant bacterial strains and promoting wound healing. This study also explores the potential systemic effects and bio-distribution of the MXene nanoparticles to ensure comprehensive safety profiling.

This work contributes to the advancement of nanomedicine, providing a novel avenue for targeted antibacterial therapy. The combination of MXene-assisted photothermal therapy with precision targeting demonstrates its potential as an advanced and adaptable strategy for combating multiresistant bacterial infections, offering hope for more effective and tailored treatment modalities in the era of antibiotic resistance.